What otc drugs cure vaginal yeast infections in one day?

Probably none: There are several otc vaginal yeast infection treatments available - most are multiple day vaginal creams. There is one that requires only one dose. One dose doesn't necessarily mean one day cure - it could take more than one day for the medication to be effective. Most of the otc yeast medications are effective about 70% of the time - if your symptoms persist, see your doctor.