Is it possible for you to drink wine while on presidone?

It increases risks: and also depends on what you are on Prednisone for. The various things for which Prednisone are used are generally not favorably influenced by alcohol. In addition, Prednisone increases the chance of stomach ulcers and bleeding, which is further increased by alcohol. If we are talking a Medrol (methylprednisolone) dose pack for bee sting or poison ivy and one glass of wine, no problem. But regular use of both may be.