Could alternating tramadol and klonopin (clonazepam) at night for plmd (not rls) be an effective solution to tolerance for both drugs?

RLS. PLMD.: That is an interesting question. I really don't see tolerance building up to clonopin in the treatment of plm d. However, if both of them work for you i don't see any problem in taking this approach. I don't believe that it has been studied. You can be your own experiment in this regard and see if it works for you in that way. It is really not a bad idea. Best wishes.

Clarification: Sounds like you have a variant of RLS termed "paroxysmal limb movement disorder in sleep" (nocturnal myoclonus), which usually responds to Dopamine agonists. Klonopin (clonazepam) typically develops rapid tolerance, and tramadol is of no value. Would recommend trial of ropinorole, pramipexole, or horizant, if not prior usage. Your daytime sleepiness might be handled with modafanil.

Probably: In general not taking a medication every day helps prevent physical and emotional tolerance. Tramadol and Klonopin (clonazepam) have different mechanisms of action. Therefore, alternating meds is an excellant plan!