Question 1

what signs would you expect to observe if organophosphate poisoning?

Accepted Answer

Water everywhere: Ops prevent the breakdown of acetylcholine. Excess of this leads to excess stimulation of the cholinergic nervous system. This is manifest by salivation, lacrimation (tears), sweating, urination, diarrhea, nausea and vomiting. The most concerning symptoms are the "killer b's" - bronchorrhea (fluid in lungs), bronchospasm (spasm of air passages) and bradycardia (slow heart rate) which can kill.

Question 2

how can organophosphate poisoning be treated?

Accepted Answer

Decontaminate: Atropine injection as soon as possible. Followed by supportive care. Person might need ventilator support for breathing until effects of OP provisioning wears off.

Question 3

hi doctors, can you tell me what is organophosphate poisoning?

Accepted Answer

It can be fatal: Organophosphates are found in insecticides, herbicides, and nerve agents. They block an enzyme that breaks down acetylcholine (ACh). As a result, ACh accumulation can cause anxiety, headache, convulsions, respiratory failure, tremor, general weakness, and potentially coma. Patients with symptoms and an exposure history should go to the closest ER. Ref: www.ncbi.nlm.nih.gov/pmc/articles/PMC2493390

Question 4

how does organophosphate poisoning cause muscular paralysis?

Accepted Answer

Inhibits AChE: Organophosphates inhibit acetocholinesterase, which is responsible for recycling actetocholine.  This leads to muscle overstimulation and rigid paralysis (amongst other things).

Question 5

when administering succinylcholine for intubation on a semi-conscious trauma pt with organophosphate poisoning, is there a dosage adjustment?

Accepted Answer

Shouldn't have to: the amount of Sch is overwhelming in an intubating dose. Also, Sch is a noncompetitive agonist, so it should work in a different mechanism than non-depolarizers.

"Semi-conscious?" - did you give an anesthetic, or does the patient look sedated b/c of the AchI effects?

Question 6

what is the physiological basis of muscle "twitching" in organophosphate poisoning?

Accepted Answer

Well...: These products simulate the action of neurotransmitters....

Question 7

how to describe poisoning by organophosphates and pesticides?

Accepted Answer

Typical scenario: This class of chemicals affects acetylcholine and can result in diffuse weakness, and difficulty breathing if excess exposure does occur, besides additional systemic and GI symptoms.  This could well develop rapidly into a medical emergency.

Question 8

what are signs of alcohol poisoning?

Accepted Answer

Liver failure: Cirrhosis is classical, such as jaundice, large belly filled with fluid, etc.  But, from the perspective of a neurologist, tremors , incoordination, gait imbalance, numbness, weakness, confusion, disorientation, epileptic seizures.  Of course, coma, delirium. Sudden death.  Not a pretty picture.

Question 9

what are the signs of acute alcohol poisoning?

Accepted Answer

See answer: Confusion, delerium, confabulation, weakness, sever fatigue, naseau, possible vomiting, tremors, and eventual comatose state.  Acute alcohol poisoning needs emergent medical attention.

Question 10

what are the signs when you get alcohol poisoning?

Accepted Answer

Serious: Alcohol is a central nervous system depressant. Drinking too much can lead to a coma and loss of protective reflexes that prevent you from aspirating and keep you breathing. People can vomit and aspirate it into their lungs. They can be so drunk, they can stop breathing. These effects are magnified if alcohol is used with other meds that are sedating, like opioids or benzodiazepines. Be careful!

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Doctor answers about:

Organophosphate poisoning signs

A member asked:

What signs would you expect to observe if organophosphate poisoning?

A member asked:

How can organophosphate poisoning be treated?

A member asked:

Hi doctors, can you tell me what is organophosphate poisoning?

A member asked:

How does organophosphate poisoning cause muscular paralysis?

A member asked:

When administering succinylcholine for intubation on a semi-conscious trauma pt with organophosphate poisoning, is there a dosage adjustment?

A member asked:

What is the physiological basis of muscle "twitching" in organophosphate poisoning?

A member asked:

How to describe poisoning by organophosphates and pesticides?

A member asked:

What are signs of alcohol poisoning?

A member asked:

What are the signs of acute alcohol poisoning?

A member asked:

What are the signs when you get alcohol poisoning?

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