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how long does benedryl take to kick in

A 43-year-old member asked:
Dr. Al Hegab
Dr. Al Hegab answered
39 years experience Allergy and Immunology
Depends: if taken on empty stomach, 30 minutes should be enough to feel its effect, if on a full stomach takes longer, check that you have taken the right dose ... Read More

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A 33-year-old member asked:
Dr. Michael Zacharisen
32 years experience Allergy and Immunology
About 3 days: The metabolism of Benadryl (diphenhydramine) or Diphenhydramine to decrease by half (called the half-life) is about 8 hours (except for children and e ... Read More
A female asked:
Dr. Charles Cattano
38 years experience Gastroenterology
Some variables here: IV is faster than oral, but what dose and for what indication (sleep, rash, allergy, etc.) are you questioning please.
A member asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience Allergy and Immunology
About an hour: It will take about an hour to take effect.
A 41-year-old member asked:
Dr. Andrew Oswari
23 years experience Family Medicine
Half life is 8 hours: Its effectiveness only lasts 6-8 hours usually. It's half life is 8 hours, so it may take up to 72 hours to leave your system completely.
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A 46-year-old member asked:
Dr. Jeffrey Rumbyrt
31 years experience Allergy and Immunology
4-6 hours: Typically, the effect of Benadryl (diphenhydramine) is 4-6 hours. It may be longer in people with liver disease.
A male asked:
Dr. David Brouwer
29 years experience Internal Medicine
ER: That is 10 times the normal dose. That person should be in the er, both for assessment of the overdose complications and the underlying reason of why ... Read More
A 39-year-old member asked:
Dr. Yash Khanna
56 years experience Family Medicine
WILL MAKE YOU SICK: It is not a good idea to overdose on 250mgm of Benadryl (diphenhydramine) to get high it can make you sick.It will cause extreme sleepiness, confusio ... Read More
A 32-year-old member asked:
Dr. Brant Ward
12 years experience Allergy and Immunology
Probably not helpful: Both drugs need to be absorbed by the GI system before they take effect to stop itching and sneezing (can take up to 1 hr). Benadryl (diphenhydramine) ... Read More
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A 37-year-old member asked:
Dr. Tammi Schlichtemeier
30 years experience Pediatrics
About 45 minutes: Benadryl (diphenhydramine) can make some people drowsy. The maximum effect occurs in about 45 minutes or so. However, it can result in hyperalertnes ... Read More
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