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Doctor insights on: Is It Good To Combine Prozac With Wellbutrin For Treatment Of Depression

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Is it good to combine Prozac with wellbutrin (bupropion) for treatment of depression?

Is it good to combine Prozac with wellbutrin (bupropion) for treatment of depression?

May be: Wellbutin blocks the uptake of norepinephrine & Dopamine while Prozac (fluoxetine) is a ssris so they effect different neurotransmitters & may work 4 u. ...Read more

Dr. Pamela Pappas
4,588 Doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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Is wellbutrin (bupropion) and prozac a good combination in addressing depression and anxiety?

Is wellbutrin (bupropion) and prozac a good combination in addressing depression and anxiety?

Use alternative: Unfortunately Prozac (while an awesome drug) can interact with quite a few medications. Usually the SSRI + Wellbutrin (bupropion) combo is a great and very commonly used therapeutic option for patients suffering with depression and anxiety. There are plenty of efficacious and safer alternatives. Hope that helps! ...Read more

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Can wellbutrin (bupropion) and prozac be used together to treat anxiety and depression?

Can wellbutrin (bupropion) and prozac be used together to treat anxiety and depression?

Sure: Could be very powerful combination because they are from different classes of medications; dose proportion of both med's is very important. ...Read more

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I'm on 80mg of Prozac, 150 mg of seroquil, 10mg brintellex and Wellbutrin (bupropion) 100mg twice a day for depression and OCD. My np doesn't want to change any.

I'm on 80mg of Prozac, 150 mg of seroquil, 10mg brintellex and Wellbutrin (bupropion) 100mg twice a day for depression and OCD. My np doesn't want to change any.

Not effective?: Need more information to understand your primary concern - is your concern the regimen is not effective, or too much? Or is your concern with the regimen itself? In general I encourage keeping an open line of communication with your provider. If your concerns remain or regimen is ineffective, a second-opinion consult may help to explore treatment options further. Be well. ...Read more

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Is a combination of 60mg of prozac and 150mg of wellbutrin xl effective for depression, anxiety, and obsessive compulsive disorder?

Is a combination of 60mg of prozac and 150mg of wellbutrin xl effective for depression, anxiety, and obsessive compulsive disorder?

For some people: This type of treatment has to be individualized for each person. Wellbutrin is good for depression but could make anxiety worse in some patients. Prozac is good for all three disorders in most people.. ...Read more

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Seeing cnp for 4 months for adult add. Tried strattera (made me depressed) now on Prozac and wellbutrin (bupropion). Mood better. Focus not. Can I ask to try stim?

Seeing cnp for 4 months for adult add. Tried strattera (made me depressed) now on Prozac and wellbutrin (bupropion). Mood better. Focus not. Can I ask to try stim?

Yes: Strattera (atomoxetine) affects norepinephrine mainly. I would have recomment sustained release Ritalin or extened release adderal for adult. Add as long as no history of substance abuse. It is a pity this patient would be on 3 medications when only one was indicated. ...Read more

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I am taking a low dose of xanax (alprazolam) but lately feel depressed and crying. What antidepressant is ok. Tried both wellbutrin and prozac with bad side effect?

I am taking a low dose of xanax (alprazolam) but lately feel depressed and crying. What antidepressant is ok. Tried both wellbutrin and prozac with bad side effect?

Unanswerable: Xanax, (alprazolam) like all benzodiazepines, can increase symptoms of depression, although it is somewhat less likely to do that than other benzos in most people. This is a question for a psychiatrist or other mental health prescriber to answer, based on the kind of depression, its severity, exactly what side effects you had, how long you used them for and many other factors. Get advice in person, not online. ...Read more

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Is Wellbutrin (100mg 2x/day), Fluoxetine (30mg) and Abilify (aripiprazole) (1mg, 2mg after a week) a safe combination for anxiety and depression?

Is Wellbutrin (100mg 2x/day), Fluoxetine (30mg) and Abilify (aripiprazole) (1mg, 2mg after a week) a safe combination for anxiety and depression?

Probably: Depending on yourneeds the combination seems reasonable. If the fluoxetine alone or in combination with wellbutrin doesn't remove/reduce depression, the addition of Abilify (aripiprazole) often helps. If, after a time this is not helpful... you didn't say you were in psychotherapy, but I would recommend it also. ...Read more

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Due to treatment of Dr. From GAD & SAD, I am doing well with combo (60mg Prozac+150mg Wellbutrin (bupropion) XL)daily morning, Is this combo safe use without harms?

Med tx: This combination is commonly used. Of course there is potential for side effects with all medications. Combining these two medications can help address problems with serotonin, norepinephrine & dopamine. ...Read more

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Take treatment for GAD by Prozac 40 mg, my GP wants add either Buspar (buspirone) or Wellbutrin to encounter side effects of Prozac, which the safe and ideal combo?

Buspirone: You may want to talk to your doc about a psychiatry referral since it sounds like (a)he may be in over their head. Buspirone is an anti-anxiety drug, but both Prozac and Wellbutrin (bupropion) can potentially exacerbate anxiety. There are many other potential options if Buspirone is not beneficial, but I would not abandon it before max dose of 60 mg/d. It should be taken 3-4 times dailu ...Read more

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Anxiety and depression have gotten severe and debilitating. Will soon be subscribed 40 mg for prozac (fluoxetine). Also in therapy. Do you think this will help me?

Anxiety and depression have gotten severe and debilitating. Will soon be subscribed 40 mg for prozac (fluoxetine). Also in therapy. Do you think this will help me?

On right track: Prozac (fluoxetine) is a good choice for treatment of anxiety and depression. Combination of medications and therapy has been shown to help in moderate to sever depression compared to medications alone. Hopefully you should feel better soon. ...Read more

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Hi, I take 60mg fluoxetine daily for depression. Over past year I have gained 20lb in weight. Is there an alternative treatment which may help?

Hi, I take 60mg fluoxetine daily for depression. Over past year I have gained 20lb in weight. Is there an alternative treatment which may help?

Therapy?: Have you yet tried any form of psychotherapy? Typically, the optimal combination of things to treat emotional issues such as depression is medication (which, on your best day, is supposed to take the edge off symptoms) but the real gruntwork takes place in psychotherapist's consulting room. ...Read more

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Is it possible that Prozac (fluoxetine) side effects won't go away. I am on 20 mg and is it good for OCD and depression?

Is it possible that Prozac (fluoxetine) side effects won't go away. I am on 20 mg and is it good for OCD and depression?

Some side effects go: Away with time- others do not (sexual side effects, for ex).

There are things to minimize effects, like take on full stomach, at bedtime etc. Best to talk to prescriber if you're having side effects.

Prozac is a good drug for OCD and depression ...Read more

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Is Prozac (fluoxetine) a good medication for depression?

Is Prozac (fluoxetine) a good medication for depression?

Excellent: Inexpensive also but like anything else, it's all about you and what works for you. Talk to your doctor. Sometimes we try several until we find what works best for you. ...Read more

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Taking 10mg Prozac for PMS. No depression at all. Will this interfere with my genuine zest for life? How likely is low libido? I have good libido now :)

Taking 10mg Prozac for PMS. No depression at all. Will this interfere with my genuine zest for life? How likely is low libido? I have good libido now :)

Prozac: If the Prozac is not impacting your libido currently - would not anticipate that it would on this dose. It is very unlikely to interfere with your zest for life. Take care. ...Read more

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Does Prozac (fluoxetine) help anxiety/panic as well as depression? I know it's a bit more activating than other ssris but wondering if it's still good for anxiety

Prozac (fluoxetine) anxiety: Prozac (fluoxetine) is still one of the best drugs for depression. It is also a great choice for obsessive compulsive disorder and bulimia nervous. Although it is not indicated for anxiety it may help in an indirect way but I would not take it if your only diagnosis is anxiety. Now days many have multiple diagnosis so it may be part of you treatment plan but not the first choice. Off label can be for panic ...Read more

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What is also good for depression and obsessive-compulsive disorder beside Prozac (fluoxetine)?

What is also good for depression and obsessive-compulsive disorder beside Prozac (fluoxetine)?

How about talking?: How about talking to the right person about things that you don't feel good about? Do you know exactly why you don't feel well? Are you doing well in school? Do you like school & your friends? Anybody in your peer group you can lean on? How about home? Is that part of the problem or do you have a sib or parent you can share things? Can I ask someone from HealthTap to comment on your situation? ...Read more

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Good day, I put on Nuzak and Wellbutrin by my GP about 4 years ago due to depression. I hate being on it and would like wean off. Any advice please?

Weaning off: It is important to check with the treating doctor about going off or lowering doses of these medications. If you have been in remission and doing well, it might be possible as long as it is slowly weaned, one by one. Your doctor must guide you and plan it with you. ...Read more

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Is wellbutrin (bupropion) good for depression and stopping smoking?

Is wellbutrin (bupropion) good for depression and stopping smoking?

Yes 4 some: Some depressed pts & some smokers are helped by wellbutrin (bupropion). ...Read more

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Is wellbutrin and effexor (venlafaxine) a good combination to treat GAD, OCD, and depression?

Is wellbutrin and effexor (venlafaxine) a good combination to treat GAD, OCD, and depression?

Everyone is diff.: Not all folks will respond the same. However this combination has been tried in so many people in the best with great results. If the symptoms worsen or noticeable side effects then follow up sooner. However many people get good response on this. ...Read more

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Is lexapro and Wellbutrin (bupropion) a good combination for post partum anxiety and depression?

Is lexapro and Wellbutrin (bupropion) a good combination for post partum anxiety and depression?

Discuss w/ OBGYN, etc: Less is best if you are breastfeeding and if one works it may be better than a mix, but ask your pediatrician and OBGYN and psychiatrist if you have one. Please consider good psychotherapy since it's a big help to make these months easier - new mother support is very important! It might even make drugs less needed. Best wishes! ...Read more

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Would wellbutrin and Vyvanse be a good combo for narcolepsy and severe apathy w depression? Pristiq (desvenlafaxine) worked but no longer

Would wellbutrin and Vyvanse be a good combo for narcolepsy and severe apathy w depression? Pristiq (desvenlafaxine) worked but no longer

Perhaps: Have you considered modafanil or xyrem [sodium oxybate]?
Stimulants like vyvanse work, and perhaps stimulating drugs like wellbutrin (bupropion).
These drugs are widely considered treatment of choice for narcolepsy. A neurology consult is in order. ...Read more

Dr. Heidi Fowler
1,053 Doctors shared insights

Fluoxetine (Definition)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better ...Read more


Dr. Alan Ali
789 Doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more