Jak2 mutation
The jak2 mutation is a genetic change found in about 9 out of 10 people with polycythemia vera (pv). Jak2 is part of a signaling system (like a thermostat) that helps tell the bone marrow when to start and stop making blood cells. Most people with pv have acquired a mutation(change) in their jak2. Because of this change, the bone marrow makes too many blood cells.
Dr. David Rosenfeld reviewed this
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A 29-year old male asked:
What is the definition or description of: jak2 mutation?
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A 54-year old female asked:
What will happen to patient with positive jak2 mutation assay? Thank you
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A female asked:
I have ET with Jak2 mutation. What should I be concerned about and is it cancer? My Hemo says no but others say yes??
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A 28-year old female asked:
Is there a correlation between sickle cell and the jak2 mutation?
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A 48-year old female asked:
I tested positive for a JAK2 mutation on a blood test and when my marrow was tested the JAK2 mutation was not found. How can this be?
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A 41-year old female asked:
I have had 2 pe's in 3 yr span, rbc is 5.38 hematocrit is 51%, hemoglobin is 17.1, negative for jak2 mutation, on xarelto 20 mg, could i still have pv?
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A 29-year old female asked:
Is it even possible to have polycythemia vera with a negative jak2 mutation? Current lab results are on previous question. Biopsy performed 04
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A 27-year old male asked:
Im a 26 year old male who lives at high altitude in Denver, CO. HGB: 18.3 HCT: 53.1 RBCs 5.9. Is this normal? I tested negative for the JAK2 mutation and my EPO was 8 my hematologist said cause was to living at high altitude?
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A 43-year old male asked:
Is there a possible link between hereditary hemochromatosis, polycythemia vera (primary jak2 mutation), & idiopathic pulmonary arterial hypertension?
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A 29-year old male asked:
Diagnosed with polycythemia vera without mutation in JAK2. What else might be the cause? Do not smoke and do not live in high altitude.
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A 42-year old asked:
What is an example of a helpful mutation in humans?
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A 49-year old asked:
What mutation causes haemochromatosis?
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A 34-year old asked:
How are sunburns and mutations related?
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A 38-year old asked:
How do cell mutations happen in fetuses?
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A member asked:
What type of mutation causes hemophilia?
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A 39-year old asked:
What type of mutation causes thalassemia?
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A 50-year old asked:
What type of mutation causes barth syndrome?
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A 30-year old asked:
What kind of mutation is involved in achondroplasia?
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A 35-year old asked:
I wanted to know is celiac a chromosome or point mutation?
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A 39-year old asked:
What is the egfr mutation test? What does its score imply?
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A 47-year old asked:
Can you tell me are chromosomal mutations always syndromes?
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A 44-year old asked:
Are there many factors that can cause the mutation for galactosemia?
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A 32-year old asked:
What is the difference between a mutation and a chromosonal abnormality?
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A 43-year old asked:
What happens if a condition is caused by a dominant mutation on an autosome:?
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A male asked:
I have factor 5 lie den mutation homozygous and I want to know if I am able to fly?
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A 25-year old male asked:
I found out i am a carrier of familial Mediterranean syndrom. Is it possible to have mild symptoms from the mutation?
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A 44-year old asked:
Can you tell me is hurler's syndrome nondisjunction, a sex-linked disorder or a type of mutation in a specific chromosome?
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A 40-year old male asked:
Can one's DNA change during life? Does that mean that different cells in my body might currently have mutations from one another?
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A 52-year old female asked:
I have a correction to make: was is caused by a mutation in the x chromosome. Females are the carriers and males are affected. ?
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A 38-year old asked:
Etiology of DNA mutations?
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