10 doctors weighed in:
Is ALS a disease of the muscles or nerves?
10 doctors weighed in

3 doctors agree
In brief: Nerve
Specifically, affects the motor nerve cell in brain and spinal cord.

In brief: Nerve
Specifically, affects the motor nerve cell in brain and spinal cord.
Dr. Bennett Machanic
Dr. Bennett Machanic
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Dr. Michele Arnold
Physical & Rehabilitation Medicine
2 doctors agree
In brief: Anterior horn cells
Als is a disease that affects nerve cells in the anterior horn (front) of the spinal cord.
This is the location of nerve cells that form the 'lower circuit' to the muscles of the face, neck, spine, arms, and legs. It results in a mix of symptoms including weakness and paralysis, spasticity and muscle spasms, hyperactive reflexes, as well as muscle twitching (fasciculations), and atrophy.

In brief: Anterior horn cells
Als is a disease that affects nerve cells in the anterior horn (front) of the spinal cord.
This is the location of nerve cells that form the 'lower circuit' to the muscles of the face, neck, spine, arms, and legs. It results in a mix of symptoms including weakness and paralysis, spasticity and muscle spasms, hyperactive reflexes, as well as muscle twitching (fasciculations), and atrophy.
Dr. Michele Arnold
Dr. Michele Arnold
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Dr. Rohit Keswani
Physical & Rehabilitation Medicine
1 doctor agrees
In brief: Nerves
Als is a disease of the nerves, affecting the central nervous system and lower motor neurons.
Since nerves ultimately supply muscles, you see the muscles being affected, but that pathology lies in the nervous system.

In brief: Nerves
Als is a disease of the nerves, affecting the central nervous system and lower motor neurons.
Since nerves ultimately supply muscles, you see the muscles being affected, but that pathology lies in the nervous system.
Dr. Rohit Keswani
Dr. Rohit Keswani
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Dr. Michael DePietro
Internal Medicine - Pulmonary Critical Care
1 doctor agrees
In brief: The nerves
Als or amyotrophic lateral sclerosis ( or "lou gehrig's disease") is a disease in which the motor nerves in the brain, or in the spinal cord degenerate and die, leaving the muscles weakened.
This is progressive and results in paralysis and even death over time. The rate of progression varies with the kind of ALS and the patient. Although the disease is not curable patients benefit from support.

In brief: The nerves
Als or amyotrophic lateral sclerosis ( or "lou gehrig's disease") is a disease in which the motor nerves in the brain, or in the spinal cord degenerate and die, leaving the muscles weakened.
This is progressive and results in paralysis and even death over time. The rate of progression varies with the kind of ALS and the patient. Although the disease is not curable patients benefit from support.
Dr. Michael DePietro
Dr. Michael DePietro
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