Only noradrenergic antidepressant works for me, does inderal (propranolol) acts negative on noradrenergic effects of antidepressant? At vasomotor centers. Regards.

Venlafaxine. It's not the vasomotor centers that are important in antidepressant response; it's the neuron synapses in the brain. Effexor (venlafaxine) inhibits reuptake of both serotonin and ne. Inderal can suppress some of the physical symptoms of anxiety (rapid heart rate, sweaty palms, tremulousness, etc). Some on chronic (not intermittent or "prn") Inderal have had more depression. Not everyone. You should be okay.