Why is my husbands lipase 450 and amylase 250 so high. They said he has cirrossis of the liver. Those are pancreatic enzyme's.

I'm sorry. Elevated lipase and amylase can result from ongoing damage to the pancreas from alcohol -- perhaps refluxing up a damaged duct, or he may have a cystic fibrosis variant, a hereditary pancreatitis, or any of several other entities. Few diseases truly involve only one organ, and he may have more than one thing going on. This sounds serious and I am glad he has you to care for & love him.