2 doctors weighed in:

Are there causes for smudge cells and high WBC other than cll?

2 doctors weighed in
Dr. Amy Deeken
Pathology
1 doctor agrees

In brief: Yes.

Smudge cells are cells that are extremely fragile and easy to disrupt the cell membrane when making a blood smear.
Therefore, if the cell is disrupted it can be very hard to identify what kind of cell it is. The most common and well known disease with smudge cells is cll. However, many other hematologic diseases also have smudge cells. Further testing is needed to be sure what cells are there.

In brief: Yes.

Smudge cells are cells that are extremely fragile and easy to disrupt the cell membrane when making a blood smear.
Therefore, if the cell is disrupted it can be very hard to identify what kind of cell it is. The most common and well known disease with smudge cells is cll. However, many other hematologic diseases also have smudge cells. Further testing is needed to be sure what cells are there.
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