8 doctors weighed in:

Is there research into any genetic, autoimmune or other condition that links nerve sheath disorders (tarlov cysts, nerve sheath tumor) with autoimmune hypophysitis targeting acth cells? Ctla-4 gene?

8 doctors weighed in
Dr. Philip Kern
Internal Medicine - Endocrinology
3 doctors agree

In brief: Immune modulation

Ipilimumab is a drug used to treat melanoma.
It targets ctla-4, which is a t cell receptor that downregulates part of the immune system. A side effect has been described: autoimmune hypophysitis (inflammation of the pituitary) which can knock out many hormones, including acth. There are a few articles on this. Torino et al, oncologist 2012; 17:525.

In brief: Immune modulation

Ipilimumab is a drug used to treat melanoma.
It targets ctla-4, which is a t cell receptor that downregulates part of the immune system. A side effect has been described: autoimmune hypophysitis (inflammation of the pituitary) which can knock out many hormones, including acth. There are a few articles on this. Torino et al, oncologist 2012; 17:525.
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