18 doctors weighed in:

What's the best treatment for, treatment resistant depression?

18 doctors weighed in
Dr. Pamela Pappas
Psychiatry
11 doctors agree

In brief: No 1 "best" one

There are many treatment augmenting strategies for treatment resistant depression.
One that seems promising but has less side effects is l-methyl folate (folic acid), (folic acid) since many with depression have abnormalities of folate (folic acid) metabolism that can worsen depression. Also there are transcranial magnetic stimulation and ect. Ongoing psychotherapy of course. Plus many complementary forms of medicine as well.

In brief: No 1 "best" one

There are many treatment augmenting strategies for treatment resistant depression.
One that seems promising but has less side effects is l-methyl folate (folic acid), (folic acid) since many with depression have abnormalities of folate (folic acid) metabolism that can worsen depression. Also there are transcranial magnetic stimulation and ect. Ongoing psychotherapy of course. Plus many complementary forms of medicine as well.
Dr. Pamela Pappas
Dr. Pamela Pappas
Thank
3 comments
Dr. Donald Jacobson
I find low dose Abilify or adding Wellbutrin to an SSRI to work best. Years ago it was a tricyclic like Pamelor with Lithium which I still use occasionally. It is often trial and error , the art of medicine.
Dr. Pamela Pappas
Thanks Dr. Jacobson. I agree with the specifics you've added here. I was struggling to fit a useful reply into that 400 character box. :-)
Dr. Anthony Vertino
Clinical Psychology
6 doctors agree

In brief: A lot of options

Medication plus psychotherapy is usually effective, even in treatment resistant depression.
Some fringe therapies are present like transmagnetic stimulation. Talk with your doctors about options that may work for you.

In brief: A lot of options

Medication plus psychotherapy is usually effective, even in treatment resistant depression.
Some fringe therapies are present like transmagnetic stimulation. Talk with your doctors about options that may work for you.
Dr. Anthony Vertino
Dr. Anthony Vertino
Thank
Dr. James Fox
Psychiatry
2 doctors agree

In brief: TMS, ECT

Also, consider transcranial magnetic stimulation (TMS) or electroconvulsive therapy (ECT).

In brief: TMS, ECT

Also, consider transcranial magnetic stimulation (TMS) or electroconvulsive therapy (ECT).
Dr. James Fox
Dr. James Fox
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