3 doctors weighed in:
Translocation or down syndrome--what is difference ?
3 doctors weighed in

Dr. James Ferguson
Pediatrics
1 doctor agrees
In brief: Few percent
Most DS result when 3 of the 21 chromosome end up in all the cells of a kid.
Data shows us that all it takes us only having a extra piece of the 21 added to the normal 46 chromosomes to trigger the physical changes of DS. This happens when mom or dad carries some miss-arranged chromosomes in a balanced (for them) way, but the kid gets extra during conception. It is found on chromosome study

In brief: Few percent
Most DS result when 3 of the 21 chromosome end up in all the cells of a kid.
Data shows us that all it takes us only having a extra piece of the 21 added to the normal 46 chromosomes to trigger the physical changes of DS. This happens when mom or dad carries some miss-arranged chromosomes in a balanced (for them) way, but the kid gets extra during conception. It is found on chromosome study
Dr. James Ferguson
Dr. James Ferguson
Thank
Dr. Danae Steele
Obstetrics & Gynecology - Maternal Fetal Medicine
In brief: Extra chromosome
Most down syndrome is because an individual has a whole extra chromosome 21 in every one of their cells.
A few individuals have part of an extra chromosome 21 instead, usually as a result of an "unbalanced translocation", which means that part of one chromosome has broken off and traded places with part of another chromosome in one of the parents. A chromosome analysis can differentiate these.

In brief: Extra chromosome
Most down syndrome is because an individual has a whole extra chromosome 21 in every one of their cells.
A few individuals have part of an extra chromosome 21 instead, usually as a result of an "unbalanced translocation", which means that part of one chromosome has broken off and traded places with part of another chromosome in one of the parents. A chromosome analysis can differentiate these.
Dr. Danae Steele
Dr. Danae Steele
Thank
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