Are there side effects to using OTC tired eye relief?

It's possible. Over the counter drops to relieve dry eyes (artificial tears, lubricant eye drops) can temporarily relieve dry eyes and the symptoms they produce. Drops that also relieve redness (visine, clear eyes, etc.) contain a chemical that constricts the blood vessels on the eye's surface, giving a temporary appearance of white eyes. Repeated use can lead to more dryness and irritation.