Taxol (paclitaxel) and hair loss. Hair loss usually begins 2-3 weeks after the first dose of taxol, (paclitaxel) although it may happen earlier. Hair usually falls out completely, but it may just thin. Patients on Taxol (paclitaxel) may also develop thinning and loss of eyelashes, eyebrows and hair in other areas of the body. This is usually temporary, and hair will start to grow back once treatment course has finished.