Remove them. First try application of over the counter medication, if fails get them removed.
Depends on the cause. Many things can cause calluses. Some reasons that one may develop a callus include: viral infections (warts), friction, pressure, repedetive trauma, and a limitation of joint motion. Some genetic conditions may also cause people to develop calluses on the hands and the feet. Treatment depends on the cause of the problem. Have it evaluated by a professional and get the appropriate treatment.