What is scleroderma?

Hard skin. Scleroderma literally means "hard skin." it is a connective tissue disease that primarily involves the skin which becomes fibrotic (hardened). Changes also may occur in the blood vessels, muscles, and internal organs. The disease involves autoimmunity whereby the immune system attacks the normal tissues of the body. The cause is unknown.
Hard Skin. In Scleroderma, autoimmune inflammation leads to fibrosis, thickening and tightening of the skin. In some cases, only the hands are affected, making fingers appear claw-like. In other cases, the arms, legs, upper back and face can also be affected. Other symptoms include Raynaud's, acid reflux from esophageal dysmotility; shortness of breath from lung fibrosis and increased pressure on the heart.
Autoimmune dysfuncti. The body gets confused at times: frequently it correlates with low vit d status + et cetera's that are not defined presently. If u take that word apart, it means scarring/stiffening of the skin. But this is a disease througout the body, especially including skin & digestive tract which then don't work correctly. It is related to lupus (sle) , rheumatoid arthitis and is a "collagen vascular disorde.

Related Questions

What causes scleroderma in people?

Unknown. The precise cause is unknown but there is a genetic predisposition in certain individuals. Viruses, certain drugs, and environmental factors have been considered as potential triggers for the onset of scleroderma in genetically susceptible persons. Read more...
I hate. As a surgeon to get involved but i lost my wife in just two years... It is an autoimmune disease of unknown origin. When just suspected a sedimentation rate, ANA levels, anti scl-70 and anti-centromere antibodies should be stat done. A good resource is this web site: http://www.Synnovation.Com/sclerodermafaq.Html i would seek help from a university based rheumatology department... Read more...

What is scleroderma crest variant?

Limited . The limited cutaneous form of systemic sclerosis is also referred to as crest syndrome. "crest" is an acronym for calcinosis, raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasia. Read more...

What makes systemic scleroderma flare?

Stress. There are no specific triggers to avoid if you have the condition. However, internal or external stress often precede a flare of scleroderma. Read more...

Funny how a diagnosis doesn't mean much till you have it. What is circumscribed scleroderma?

Morphea. Complex localized condition, skin biopsy can be useful. There are some suggested treatment if condition severe enough. Read more...
Not as severe. Circumscibed scleroderma is an area of thickened skin when felt and biopsied looks like scleroderma. It is different then two other and more serious scleroderma diseases which are limited scleroderma and the most severe diffuse scleroderma. Usually, circumscribed scleroderma is not associated with other sysytemic problems amd makes much less severe as compared to the other scleroderma diseases. Read more...

What is morphoea localised scleroderma?

Limited disease . Morphea or localized scleroderma is scleroderma limited to isolated areas of skin that have hardened. This occurs as a result of excessice collagen deposits in the skin. In morphea there is generally no associated systemic (internal organ) involvement. Read more...

What is morphea also scleroderma?

Sort of. Morphea is a localized patch of scleroderma (hard skin) that is generally not associated with the systemic manifestations of scleroderma or systemic sclerosis. Read more...
Skin only. Morphea is a form of scleroderma ("hard skin") that is localized and only affects the skin. There is no associated internal organ involvement. Read more...

What are the tests for scleroderma?

Scleroderma tests. The diagnosis of scleroderma is based mostly on signs and symptoms. Lab tests may help confirm the diagnosis and even offer some predictions as to risks of certain types of complications. Anti rna-polymerase iii antibody, increases risk of renal crisis and sudden increase in blood pressure, antitopoisomerase ab, increases risk for scaring of the lung, anticentromere ab, pulmonary hypertension. Read more...
History & Physical. The most important test is a history and physical, under the guidance of your physician, and rheumatologist, the dermatologist. We have blood tests that can be run that can help guide the diagnosis, as well as tests to look for the systemic involvement of scleroderma such as the lungs and kidneys. Each person is different, and each person has to be evaluated individually and classified accordingly. Read more...

What are common symptoms of scleroderma?

Skin changes. The first sign is usually patchy areas on the skin that often make a linear pattern. Early on, they are slightly pink and thickened, but can be flat and shiny. As time passes, the skin spots enlarge and often become thick and lavender/purple-colored, sometimes with pale flat centers. Scleroderma can also affect the heart, lung, kidney, joints, digestive tract. Please see your doctor if you're worried. Read more...

What are signs, symptoms of scleroderma?

Tight skin. People with scleroderma have tight skin, but have other findings including raynauds, finger changing color in the cold or stress, joint pain, and can have internal involvement in the lungs, heart, kidney etc. Each person has different finding and the rheumatologist helps to put it together. Read more...
Hard Skin. In Scleroderma, autoimmune inflammation leads to fibrosis, thickening and tightening of the skin. In some cases, only the hands are affected, making fingers appear claw-like. In other cases, the arms, legs, upper back and face can also be affected. Other symptoms include Raynaud's, acid reflux from esophageal dysmotility; shortness of breath from lung fibrosis and increased pressure on the heart. Read more...