2 doctors weighed in:

Are fexofenadine HCl and diphenhydramine HCl the same?

2 doctors weighed in
Dr. John Norvell
Internal Medicine - Allergy & Immunology
1 doctor agrees

In brief: No

Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used.
Fexofenadine is a second-generation, non-sedating antihistamine which should have more lasting effects, closer to 24 hours, and is less likely to make you sleepy.

In brief: No

Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used.
Fexofenadine is a second-generation, non-sedating antihistamine which should have more lasting effects, closer to 24 hours, and is less likely to make you sleepy.
Dr. John Norvell
Dr. John Norvell
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