3 doctors weighed in:

Is weight gain from Effexor (venlafaxine) metabolic?

3 doctors weighed in
2 doctors agree

In brief: Not certain

No one is certain as to what causes weight gain on Effexor (venlafaxine) in some patients.
For some, Effexor (venlafaxine) might decrease the sense of satiety, or fullness, causing people to eat more than usual. We know that some people have a genetic predisposition to increased side effects to ssris, involving their effect on the serotonin 2a receptor, which has an impact on appetite.

In brief: Not certain

No one is certain as to what causes weight gain on Effexor (venlafaxine) in some patients.
For some, Effexor (venlafaxine) might decrease the sense of satiety, or fullness, causing people to eat more than usual. We know that some people have a genetic predisposition to increased side effects to ssris, involving their effect on the serotonin 2a receptor, which has an impact on appetite.
Dr. Robert Berkowitz
Dr. Robert Berkowitz
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