I have mthfr c677t homozygous mutation, history of rectal cancer ([email protected]). Are these related? What is the serum folate (folic acid) level I should aim if want pregnant?

Not related. These are not related. Also recent data shows no clinical significance of having a mrhfr mutation. It is safe for pregnancy and there is no increase risk for miscarriage other than your normal risk factors. Do not need to follow folate (folic acid) or homocysteine levels.
Junk science. Forgive my frankness. C677t is a no big deal & 10% of folks are like you. Eat sensibly &/or take folate (folic acid) if you want to conceive like anyone else. The push for mthfr typing is the work of a militant lab & i doubt its usefulness. I saw the little study from red china correlating this allele to lung cancer; it makes no sense biologically and the numbers are barely significant; i'm ignoring it.
No. Mthfr 677 does not affect colorectal cancer risk although it can increase risk of certain other cancers. Titrate folate (folic acid) intake to homocysteine level. If homocysteine is between 5-7, your folate (folic acid) intake is adequate. Do not take Folic Acid but rather take metafolin. http://drfairchild.blogspot.com/2013/08/homocysteine.html.

Related Questions

I am hetero for the mthfr genetic mutation c677t. Everything I've read says I should be gluten/folic acid/dairy free. Advice regarding this mutation?

Spectracell lab. In tx has a test for this. Since you are pos. For it, you can visit their site for info or call them. Peace and good health. Read more...
I can't agree. ~1 person in 4 is like you. The pathology community is divided over MTHFR testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor. . Read more...
Not so extreme but.. This is common, affecting up to 50% of people,but the homozygous mutation is much more significant than hetero.Those with it have increased risk of depression, anxiety,cardiovascular disease etc. but it's just one of thousands of genes. My best advice is get a fasting homocysteine test; if 10 or higher take a multivit. with the L-5MTHF form of folate. See https://tinyurl.com/yacd86e4 and comment: Read more...

I am pregnant and have a mthfr gene mutation and I recently read that folic acid is not good for me or the baby and I should take folate instead?

Folic acid is folate (folic acid) Folic acid and folate are the same compound. Follow your gynecologists and hematologists recommendations. Folate is often prescribed during pregnancy in the field of psychiatry and neurology when patients are on anticonvulsants. I too have the same mutation that you have and i take folate every day. I have also been advised to take vitamin b6 and vitamin b 12 because of this. Your child should also be tested for this mutation and anyone else in your family.Best wishes. Read more...
MTHFR. If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too. Read more...
Folic acid is bad. Folic acid is synthetic folate, and needs extra metabolic steps to turn it into a usable form. The body is very slow to convert it, and unmetabolized folic acid downregulates your folate receptors and folate binding proteins. This is a bad thing. Avoid folic acid, and take methylfolate instead. Read more...

Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Controversial... Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! Read more...