Still confused about estrogen, hormone replacement therapy and cardiovascular disease?

Complex issues. Female hormones increase thromboembolism, deep venous thrombosis--progesteron is blamed, more than estrogen--because at menopause, there is changes in blood coagulation?Increase weight, arteriosclerosis, metabolic syndrome all of this increase risk of cardiovascular disease-- estrogen can be given at low dose for brief periods.
Not good. Based on the randomized controlled trial - women's health initiative - hormone therapy is not protective for cardiovascular disease and my even cause strokes, along with blood clots, etc. Bottom line: not recommended for cardiac prevention. If you are young and early postmenopausal with symptoms and have no cardiac disease, short course (1-2 years) may be ok. Talk to your doctor before starting it.
Start early. From the hers study based on long term study of nurses in the uk, early use of hrt is cardioprotective. If, like the whi study, hrt is started at the average age of 61, there is an increased risk of blood clots, heart attack etc.

Related Questions

Whats the latest on hormone replacement therapy and cardiovascular disease?

Necessary ! Optimal and balanced hormones have been preven to reduce the risk of cardiovascular disease, heart attack, and stroke. Read more...
In women. When i was on the faculty of a medical school, i used to teach that women that did not take hormone replacement had a higher risk of cardiovascular disease than men at the same age. I think it needs to be started early and continued for the cardiovascular protective effect. Just my opinion. Many will disagree with me. But this statement is based on the hers study going on for many years. Read more...

What are healthy blood levels of estrogen when on hormone replacement therapy?

Invalid. There is no validity to following blood estrogen levels in order to adjust the dosage of hormone replacement. At age 32, I would not expect that you should need hormone replacement, unless you went through early menopause or had surgical removal of your ovaries. In postmenopausal women the dose is adjusted based on symptoms (hot flashes, sleep issues), not blood levels. Read more...

What are your views on hormone replacement therapy involving the use of premarin (conjugated estrogens)?

Only use for 1 thing. Hi. I know I'll get jumped all over for this, but I'd only consider systemic estrogen for one thing in postmenopausal women: relief of menopausal symptoms that can't be relieved any other way. To me, the risks outweigh the benefits. I'll get bruised & bloodied for saying that! Vaginal estrogen is fine & safe for atrophy of vaginal mucosa after menopause. Making Premarin (conjugated estrogens) is not nice for the mares! Read more...

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual. Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. Read more...

Does hormone replacement therapy (hrt) increase a woman's risk for heart disease or not?

Yes and no. It reduces the risk of developing plaque which reduces long term risk. However, it increases the risk of forming clots, especially in smokers, which is the final step leading to stroke or heart attack. Read more...

What's my risk of heart disease after a hysterectomy? My doctor recommended a hysterectomy and hormone replacement therapy, but I've read it can increase my risk of heart disease. I already have some risk factors. Does a hysterectomy make my chances of de

Hello. . Hello. If you ovaries are not removed; it won't change your risk for heart disease. However if both your ovaries and uterus are removed (which it looks like is the case for you since your doctor is recommending hormone replacement therapy) that can increase risk. With a total hysterectomy your estogen levels will drop. Estrogen helps to protect against heart disease. You develop a "surgical menopause" and this can lead to increasing sustances in your blood that cause clotting as well as making your blood vessels more susceptible to plaques or clots forming. Read more...
Heart disease. The risk of heart disease increases after a hysterectomy due to the decline in estrogen that has protective actions toward heart disease. I would look into bio-identical hormone replacement. Read more...