Sometimes. Some lymphangiomas that occur in utero can be due to genetic disorders such as noonan syndrome, trisomy 13, trisomy 18, trisomy 21, and turner syndrome. Some are acquired and have no obvious genetic cause.
Yes and No. About 70% 0f lymphangiomas are seen associatted with genetic syndromes. It is frequently seen in patients with turner syndrome (x0) & occasionally seen in Down syndrome (trisomy 21) and others. It also occurs sporadicly in otherwise normal kids. The largest one I ever saw was locates over the trunk and side of a normal kid.
Yes. Most lymphatic malformations are not associated with genetic disorders. However, those that are diagnosed by prenatal ultrasound are frequently associated with chromosomal anomalies. These associations include down's syndrome, turner's syndrome, klippel-trenaunay syndrome, and congenital glaucoma.