Can any of the acne medications lighten up my freckles?

Freckles. Lentigines require no specific treatment. A broad-spectrum sunscreen may help to prevent further appearance and darkening of solar lentigines. Several creams may lighten lentigines if applied for a number of months. These include hydroquinone or antioxidants: Alpha hydroxy acids, vitamin c, retinoids, azelaic acid. Liquid nitrogen is also very effective.