9 doctors weighed in:
What percentage of neurofibromatosis is random, in which no family members have it but you?
9 doctors weighed in

5 doctors agree
In brief: Rare
Non genetic mutation, causing neurofibromatosis is rare.
In nf-1 chromosome 17 is involved nf-2 chro. 22 is involved, autosomal dominant transmission that means 50% chances the offspring will inherit the disease.

In brief: Rare
Non genetic mutation, causing neurofibromatosis is rare.
In nf-1 chromosome 17 is involved nf-2 chro. 22 is involved, autosomal dominant transmission that means 50% chances the offspring will inherit the disease.
Dr. Addagada Rao
Dr. Addagada Rao
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Dr. Scott McLean
Clinical Genetics
1 doctor agrees
In brief: About half
Neurofibromatosis type 1, also known as nf1 or von recklinghausen's disease, is caused by alterations to a gene on chromosome 17.
These mutations can be passed from parent to child or, about 50% of the time, they happen as a new event in the dna of either the egg or the sperm before fertilization. It's always wise, when 1 person is diagnosed with nf1, to have all of their close relatives examined.

In brief: About half
Neurofibromatosis type 1, also known as nf1 or von recklinghausen's disease, is caused by alterations to a gene on chromosome 17.
These mutations can be passed from parent to child or, about 50% of the time, they happen as a new event in the dna of either the egg or the sperm before fertilization. It's always wise, when 1 person is diagnosed with nf1, to have all of their close relatives examined.
Dr. Scott McLean
Dr. Scott McLean
Thank
Dr. Gerald Mandell
Nuclear Medicine
In brief: Fifty percent
Estimated incidence of NF1 is 1 in 3000.
Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation. Therefore 1 in 1500 are new cases.

In brief: Fifty percent
Estimated incidence of NF1 is 1 in 3000.
Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation. Therefore 1 in 1500 are new cases.
Dr. Gerald Mandell
Dr. Gerald Mandell
Thank
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