If a girl gets her HPV shots in middle school, won't the protection have dropped a lot by her college years?

Probably not. Gardasil, the most common hpv vaccine, protects against 4 types of hpv which collectively cause the majority of genital warts and cervical cancers. So far, Gardasil has been shown to be fully protective after 5 years. Ongoing studies will determine if a booster is needed. Since 70 percent of teens will have intercourse by age 19, earlier vaccination is recommended.