2 doctors weighed in:

What genetic testing can be done for sudden unexplained death besides lqts?

2 doctors weighed in
Dr. Alex Golden
Pediatrics - Cardiology

In brief: Many

Hypertrophic cardiomyopathy dilated cardiomyopathy arrhythmogenic right ventricle brugada syndrome short qt syndrome catecholamine driven polymorphic vt ..
. And others, too. Check out www.Sads.Org for more information. Of course, there can be non-genetic causes of sudden death as well.

In brief: Many

Hypertrophic cardiomyopathy dilated cardiomyopathy arrhythmogenic right ventricle brugada syndrome short qt syndrome catecholamine driven polymorphic vt ..
. And others, too. Check out www.Sads.Org for more information. Of course, there can be non-genetic causes of sudden death as well.
Dr. Alex Golden
Dr. Alex Golden
Thank
Dr. Jared Adams
General Practice

In brief: Molecular autopsy

Up to one third of sudden deaths in "structurally normal hearts" may harbor a genetic defect related to a channelopathy (e.
g. Lqts, cpvt, brs, sqts). Cardiomyopathies can result in sudden death even when the structural anomalies are minimal (e.g. Arvc or hcm related to mutations in the tnnt2 gene). Genetic testing is possible for these conditions but yield is <25%. Lqts is the only "good" test.

In brief: Molecular autopsy

Up to one third of sudden deaths in "structurally normal hearts" may harbor a genetic defect related to a channelopathy (e.
g. Lqts, cpvt, brs, sqts). Cardiomyopathies can result in sudden death even when the structural anomalies are minimal (e.g. Arvc or hcm related to mutations in the tnnt2 gene). Genetic testing is possible for these conditions but yield is <25%. Lqts is the only "good" test.
Dr. Jared Adams
Dr. Jared Adams
Thank
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