Can prednisone mouthwash help geographic tongue?

It may help symptoms. There is no cure for geographic tongue and there is usually no reason to try and treat it. If you are having sensitivity Prednisone may help decrease some inflammation.
Geographic Tongue. No medical intervention is required because the lesion is benign and most often asymptomatic.However, abe et al report successful treatment with cyclosporin, and sigal and mock reported treatment with topical and systemic antihistamines. Topical retinoids and topical corticosteroids are occasionally of benefit. In psoriatic patients, the lesions may resolve during systemic therapy for psoriasis.