What does having itching all over signify?

Itching. Because the causes of widespread itching can vary from lots of benign things to some very bad things you should really see a doctor. Most causes are benign though.
Need to see md. This is a reaction to an outside allergen such as laundry interment, an infection with scabies, or a reqction to any number of things sich as a medication, an internal infection , a food al ergy or rarely a cancer such as lymphoma. Calamaine can help temporarily, but you need an extensive history, exam, and blood tests to look for cause.