Smoking cigarette after done with fractional co2 laser procedure, will it affect the skin rejuvenation process?

Prevention. The best thing you can do for your skin is to prevent injury. This includes stopping smoking. Smoking chokes the small blood vessels that provide the skin nutrition. It causes premature aging, and wrinkles. It will slow you healing after any surgery or skin resurfacing and should be discontinued today.
Absolutely-BothToxic. Co2 laser is simply a way of applying heat to damage/kill cells, for whatever "cosmetic" goal, but definitely a toxin in & off itself. Smoke of burning substances, cigarettes studied longest & most widely, contains huge numbers of toxins being inhaled into far more fragile tissues, the cells lining the bronchi & alveoli. Tobacco smoke promotes bronchitis, emphysema, atherosclerosis & cancers.