2 doctors weighed in:

Im passing asacol (mesalamine) out whole. Does colazal release differently than asacol (mesalamine) or is it also pH dependent? And does it work the same?

2 doctors weighed in
Dr. You Sung Sang
Internal Medicine - Gastroenterology
1 doctor agrees

In brief: Different release

While Asacol (mesalamine) release is ph dependent, Colazal does not become active until the drug reaches the colon where bacteria there splits the drug up into an active state.
In fact, the capsule is just a formality as the Colazal powder can be swallowed whole - as it is available overseas. Having said that, many of my patients also see intact Asacol (mesalamine) tabs in their stools.

In brief: Different release

While Asacol (mesalamine) release is ph dependent, Colazal does not become active until the drug reaches the colon where bacteria there splits the drug up into an active state.
In fact, the capsule is just a formality as the Colazal powder can be swallowed whole - as it is available overseas. Having said that, many of my patients also see intact Asacol (mesalamine) tabs in their stools.
Dr. You Sung Sang
Dr. You Sung Sang
Thank
Get help from a real doctor now
Dr. Peter Kurzweil
Board Certified, Internal Medicine
47 years in practice
16M people helped
Continue
111,000 doctors available
Read more answers from doctors