What is the treatment for lead overdose that is best and has fewest side effects?

Lead poisoning. In most cases of lead poisoning, removal from exposure is the only therapy needed. If blood lead levels exceed a certain concentration, chelation therapy may be necessary, which is really a clinical judgment call. Exposure to lead must cease before chelation therapy begins. Dmsa (succimer) is fda-approved for lead-poisoned children, and is effective in adults. It is taken by mouth.