What choices do I have for treating leptospirosis?

A few choices. If the patient isn't so sick, then oral Doxycycline is a good choice. In sicker patients, penicillin g IV therapy is preferred. More recent trials have shown that third-generation cephalosporins are as effective as Doxycycline and penicillin in treating this disease. The crucial step is to actually be thinking about this diagnosis in the right situation.