What are the safest home remedies for pleurisy?

Your car. Use it to drive to your doctor who can make sure your pleurisy is not a more serious problem. Once that is done, then use it to drive to the pharmacy to pick up some Ibuprofen or Aspirin for the pain. Sorry for the sarcasm, but "home remedies" should be reserved for things like colds, sore throats, mild headahces, bruises etc, pleurisy can be mild/self limited, but it can signify serious illness.