Does Depakote cause brain atrophy? If it does, is it reversible if Depakote is discontinued?

Not in an adults. Depakote or valproic acid does not cause cell loss (atrophy) in an adult brain. Bit, it can cause apoptosis of increased cell death in a developing brain. It has been linked with cognitive difficulty when a fetus is exposed to this drug from mothers taking it during pregnancy. It may lead to a lower iq and reduced verbal abilities.