Why is secondary IgM deficiency seen in whipple's disease? I thought infection did not reduce immunoglobulin levels.

Protein-losing Enter. Protein-losing enteropathy is characterized by excessive loss of serum proteins into the gastrointestinal tract. Lymphopenia is a common finding associated with protein-losing enteropathy due to whipple disease. In addition to the loss of albumin, components of lymph are also lost into the bowel, including lymphocytes, immunoglobulins, as well as fat-soluble vitamins, lipids & cholesterol.