Estrogen decreases. Estrogen is an important hormone in both women and men. In women, it is produced by the ovary as long as ovulation is occurring, but after menopause (average age 52), this stops. The ovary still produces testosterone, as does the male testes, and this can be converted to estrogen, but in many persons, the production of testosterone also drops after age 75.
It looks like. Bimodal, during prepubertal stage they are on the low side and then increase during puberty. There is fluctuation during different phases of menstruation. They will peak during pregnancy and decline in postmenopausal state, .