7 doctors weighed in:

For a stage III b colon cancer removed surgically, why the chemo should be systemic rather than regional although there are no metastasis?

7 doctors weighed in
Dr. Michael Ginsburg
Radiology - Interventional
4 doctors agree

In brief: Micrometastasis

The goal of adjuvant therapy is the eradication of occult micrometastatic tumor cells before metastatic disease becomes clinically evident.
Undetected micrometastases can contribute to the failure of primary treatment. Adjuvant chemotherapy for stage iii colon cancer dramatically improves both relapse-free and overall survival.

In brief: Micrometastasis

The goal of adjuvant therapy is the eradication of occult micrometastatic tumor cells before metastatic disease becomes clinically evident.
Undetected micrometastases can contribute to the failure of primary treatment. Adjuvant chemotherapy for stage iii colon cancer dramatically improves both relapse-free and overall survival.
Dr. Michael Ginsburg
Dr. Michael Ginsburg
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1 comment
Dr. Benjamin Kim
Unlike systemic treatments, regional adjuvant therapy for Stage IIIb colon cancer has not been tested in randomized trials. The major recurrences are systemic, most often the liver. REgional therapies to date are more difficult to administer(e.g. IP, selective vascular perfusion) and has no clear advantage for addressing distance mets. usion
1 doctor agrees

In brief: Several reasons

In stage iii b there is metastasis to few lymph nodes , not to the adjacent organs, it is possible to have invisible dormant undetected tumor cells in the body , adjuvant chemotherapy is given to kill or eliminate these cells , regional chemotherapy through inf.
Mesenteric vessels will damage normal organs , need systemic control of the disease.

In brief: Several reasons

In stage iii b there is metastasis to few lymph nodes , not to the adjacent organs, it is possible to have invisible dormant undetected tumor cells in the body , adjuvant chemotherapy is given to kill or eliminate these cells , regional chemotherapy through inf.
Mesenteric vessels will damage normal organs , need systemic control of the disease.
Dr. Addagada Rao
Dr. Addagada Rao
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