I take Prilosec in morning and Zantac (ranitidine) at bedtime. Zantac (ranitidine) helped at night for a while. But now it isn't. What can I do.

Increase the prilose. You may take an additional Prilosec at bedtime, or see your doctor for a rx strength medication. An antacid as an additional medication may also be helpful. If you have symptoms of relux over 2 times a week which are unrelieved with over the counter medications, (burning from acid in your esophagus) you should seeyour dr.