9 doctors weighed in:
Chemotherapy for bowel cancer yes or no: stage 2a pt3 n0 mx, 1-2 mm margin of fat to serosa, moderately differentiated @ splenic flexure. Thankyou?
9 doctors weighed in

Dr. Liawaty Ho
Internal Medicine - Hematology & Oncology
7 doctors agree
In brief: Stage IIA colon ca
Routine use of chemo for stage ii colon cancer is not recommended.
For stage ii, chemo was associated with a small improvement in disease free survival that ranged from 4 to 7% but no overall survival benefit. In high risk stage ii ( lymph node taken <13; margin +/close, poorly diff, perforation, T4 etc) chemo either using 5fu or 5fu+oxaliplatin can be considered. Please discuss with your doctor.

In brief: Stage IIA colon ca
Routine use of chemo for stage ii colon cancer is not recommended.
For stage ii, chemo was associated with a small improvement in disease free survival that ranged from 4 to 7% but no overall survival benefit. In high risk stage ii ( lymph node taken <13; margin +/close, poorly diff, perforation, T4 etc) chemo either using 5fu or 5fu+oxaliplatin can be considered. Please discuss with your doctor.
Dr. Liawaty Ho
Dr. Liawaty Ho
Thank
1 comment
Dr. Michael Thompson
Additionally micro-satellite instability (MSI) testing can be done to further risk stratify. MSI testing may be done by IHC (MSI-H=MSI or MSS) or DNA testing (MSI-H or –L)
Dr. Carlo Contreras
Surgery - Oncology
In brief: No
The majority of oncologists would not administer chemotherapy in this situation.
Large trials have failed to show a consistent benefit for patients with these tumor characteristics. Chemotherapy is usually reserved for node-positive colon cancer. That being said, every patient is different and deserves a personalized conversation regarding the risks and benefits of chemotherapy.

In brief: No
The majority of oncologists would not administer chemotherapy in this situation.
Large trials have failed to show a consistent benefit for patients with these tumor characteristics. Chemotherapy is usually reserved for node-positive colon cancer. That being said, every patient is different and deserves a personalized conversation regarding the risks and benefits of chemotherapy.
Dr. Carlo Contreras
Dr. Carlo Contreras
Thank
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