15 doctors weighed in:

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

15 doctors weighed in
Tim Markman
General Practice
8 doctors agree

In brief: Estrogen

Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors.
Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy.

In brief: Estrogen

Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors.
Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy.
Tim Markman
Tim Markman
Answer assisted by Tim Markman, Medical Student
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1 comment
Dr. Neil Liebowitz
Be mindful that certain medications such as Paxil, Prozac and Wellbutrin may render tamoxifen ineffective due to interference with its metabolism (tamoxifen must be metabolized to work) Always tell all your doctors about all medications and suppliments that your are taking. Even St.Johns Wort is known to interfer with treatment for HIV.
Dr. Denise Elser
Gynecology
6 doctors agree

In brief: Estrogen

Tamoxifen is an anti- estrogen in the breast, but can act like estrogen in other organs, notably the uterus.
Women on tamoxifen, who have not had a hysterectomy, need to have a gyne keep a close eye on uterine health.

In brief: Estrogen

Tamoxifen is an anti- estrogen in the breast, but can act like estrogen in other organs, notably the uterus.
Women on tamoxifen, who have not had a hysterectomy, need to have a gyne keep a close eye on uterine health.
Dr. Denise Elser
Dr. Denise Elser
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Dr. Barry Rosen
Surgery
5 doctors agree

In brief: It's complicated

Tamoxifen is a selective estrogen receptor modulator which competes with estrogen to block this receptor on cancer (and other) cells.
It does not suppress production of either estrogen or progesterone. Ironically, it is effective against breast cancer cells that harbor either the estrogen or Progesterone receptors (although, tumors that are estrogen rec. (-) and Progesterone rec.(+)are rare.).

In brief: It's complicated

Tamoxifen is a selective estrogen receptor modulator which competes with estrogen to block this receptor on cancer (and other) cells.
It does not suppress production of either estrogen or progesterone. Ironically, it is effective against breast cancer cells that harbor either the estrogen or Progesterone receptors (although, tumors that are estrogen rec. (-) and Progesterone rec.(+)are rare.).
Dr. Barry Rosen
Dr. Barry Rosen
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