3 doctors weighed in:

On the the trazodone it says "avoid alcohol and grape fruit juice, why?

3 doctors weighed in
Dr. Patrick Tapia
Psychiatry
2 doctors agree

In brief: Interactions

Trazodone is a sleep medicine and alcohol puts you to a sleep harder so it makes sense to avoid them in combination.
Grapefruit has a famous interaction with many medicines because they have compounds called furanocoumarins that inhibit proteins including cyp3a4 and p-glycoprotein. This results in unpredictable effects on many other medications, and trazodone is broken down by cyp3a4.

In brief: Interactions

Trazodone is a sleep medicine and alcohol puts you to a sleep harder so it makes sense to avoid them in combination.
Grapefruit has a famous interaction with many medicines because they have compounds called furanocoumarins that inhibit proteins including cyp3a4 and p-glycoprotein. This results in unpredictable effects on many other medications, and trazodone is broken down by cyp3a4.
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