What's the best treatment to get rid of enlarged lymph nodes?

Cause? Treatment is dependent on the etiology/cause/diagnosis of the enlarged lymph nodes.
It depends. You need to know first what is the cause of the enlarged lymph nodes. There are a lot of things that can make your lymph nodes enlarged. You will need to rule out infections, autoimmune disorders, immunodeficiency syndrome, malignancy etc. The best treatment has to be directed to the etiology/ cause of the problem.