Can affect fertility. If your brain isn't signalling for an egg release from your ovary, you won't have a signal for your periods either; that's usually the cause of amenorrhea. Often it's a hormonal imbalance--Thyroid, Prolactin, LH, FSH, Hcg should be checked. Your doctor can also induce a period as well w/ OCPs. If you've NEVER had a period, you should get an US to make sure you have normal uterus/vagina/ovaries.