What is hla-typing or "tissue typing? " what is tissue crossmatch?

Donor-Recipient. These are all methods of determining compatibility between donor and recipient with organ and tissue transplants. Everyone has certain protein and carbohydrate markers on the outside of every cell. These make us unique, but also are potential allergens between people. To help prevent rejection (which can be life-threatening) we try to make sure the markers are alike as possible in both people.
HLA typing. Human leukocyte antigen or hla typing is a very sensitive and specific testing that is done to determine whether a patient may have specific preformed antibodies to any of the proteins or antigens typically present on the cells. This is like marching fingerprints. This testing can help predict whether a recipient may reject the organ from a donor and helps get the right organ to the righ recipient.

Related Questions

What is the definition or description of: hla typing?

HLA typing. Describes the determination of proteins on the cell surface which the immune system utilizes to assign self and not self. There are multiple genes which encode these proteins on chromosome 6. Read more...

What are indications of hla typing?

Immunology. Usually hla typing is performed to look for immune compatibility (or lack thereof). Examples include transplant, platelet transfusion, and certain autoimmune diseases. Read more...

My 34 yr old sister had an hla typing for celiac disease and came back positive for hla dq2.Should she be concerened? Is this something serious?

Depends. Dq2 could indicate gluten sensitivity. Markers associated with celiac are hla dq Alpha 0501, hla dq beta 0201 or 0302. Read more...
Depends. Dq 2 is associated with celiac disease. Did she have the specific subtype identified? Testing further the different subtypes and alleles can give an idea of what the risk of celiac disease to develop if ttg antibody is negative tight now. Celiac id from prometheus labs is one such test. They result out your actual subtype, and then give a risk assessment of how likely for celiac's to develop. Read more...
Not very helpful. Everybody gets four out of a lottery of several hundred hla antigens (two from each parent). Some of the autoimmune diseases are more common in people with particular hla antigens. Except for hla-b27 and enthesopathy, i've never seen the point in this kind of testing when more sensitive and specific methods of diagnosis are available. It upsets people ; generates misunderstanding. Read more...

With regards to hla typing, is mhc-1 matching or mhc-2 better to avoid a graft rejection?

In the arena of stem. Cell transplantation this is more defined than in the past. Class one match (hla a, b and c) and class two (hla dr and dq) are all performed at high resolution (gene level tryping). The best match with all loci evaluated will produce the lowest chance of graft rejection. Mis-match can be assessed in the gvhd and host vs graft (rejection) direction. Read more...