Does grapefruit juice interact with aspirin or ibuprofen?

Grapefruit juice . And other citrus fruits may interact with many medications but no significant interactions with Aspirin or ibuprofen. Citrus may interfere with the hepatic and intestinal enzyme cytochrome p450 isoform cyp3a4. A pharmacist can check drug interactions for you.
A valuable resource. You can use a drug interaction checker whenever you have questions about drug-drug interactions or drug - food interactions. Here is one option (Drugs.Com): Your pharmacist is also an excellent source of information.