Are there some genetic reasons I get foot swelling off and on?

Not likely. There are many more common and likely reasons that you notice swelling in your foot, but it's necessary to distinguish if it is one or both feet, symmetric, when it occurs (constant, cyclical), how severe it is, family history, your age and medical history, bloodwork, etc. Before being able to narrow down for you the most likely cause.
Hard to identify. While it is always theoretically possible to have some genetic reasons for foot swelling, more than likely there is not a specific genetic cause. Some people can have clotting disorders that cause thrombophlebitis and leg swelling; others can have inflammatory conditions. Given that your symptoms are intermittent, however, it is unlikely, as there are far more common causes.
Some genetic links. Some causes of swelling of the feet can include systemic problems such as hypertension, and problems with the kidneys and localized issues such as arthritis, infection, lymphatic obstruction, blood clots, varicose veins, trauma (fracture, sprain, tendonitis) and side effects to medication. Have it evaluated by a professional and get the appropriate treatment.

Related Questions

Foot swelling and pain for no apparent reason?

Sometimes. We can even twist our foot in bed or even unknowingly . Also varicose veins can cause it if you have deep ones, but you would usually have smaller ones on the surface. If both sides were swelling the causes would be more in number but much more limited since one sided.. Apply ice or heat and try Ibuprofen or aleve, (naproxen) limit salt and elevate the leg. An ace wrap might help too. Read more...
There is. always a reason….the trick is to find it…. Read more...

Foot swelling for no reason and it looks like I have an allergic reaction. It hurts its a shooting pain but I don't know what caused this?

Evaluation needed. Allergic reactions limited to one foot is a bit unusual. It will be important for the treating physician to distinguish between soft tissue, swelling, joint swelling, and angioedema from allergic reaction. Frequently with allergic reaction there is itching and redness and less "shooting pain." insect bite or sting reactions may be a possibility and a close examination will aid in this. Read more...