Can rhodiola rosea interact with ssri (zoloft)?

Yes. Rhodiola rosea can be a very helpful herb, but it can interact with zoloft and other ssri's. It is a potent inhibitor of certain liver enzymes that metabolize zoloft and others. because of this, there could be a risk of serotonin syndrome. There is also a published report of tachyarrhythmia when rhodiola was taken with lexapro (escitalopram).