Can rhodiola rosea interact with ssri (zoloft)?

Yes. Rhodiola rosea can be a very helpful herb, but it can interact with zoloft and other ssri's. It is a potent inhibitor of certain liver enzymes that metabolize zoloft and others. because of this, there could be a risk of serotonin syndrome. There is also a published report of tachyarrhythmia when rhodiola was taken with lexapro (escitalopram).
Interaction. Agree with Dr. Pappas. You can use an interaction checker when you have questions about drug interactions with herbal or natural medications. Here is one example: