Asking about possible interaction between 60mg of prednisone and. 50mg of Xanax (alprazolam) with a gap of eight hours?

None. Widely used medications. There is no interaction that i would know of. That would be next to unheard of. However, 60 Prednisone is a relatively high dose and the question is why you need it. Check with your doc. But no drug drug interaction.