Does it matter if femara (letrozole) is taken in the morning vs evening?

No matter. There are several reasons to take Femara (letrozole) but it should not matter when you take the medication regarding the benefits of its use. It can cause symptoms with dizziness and some people choose to take it before bedtime. You should discuss your other medications with your provider, specifically if you are on thyroid or cholesterol meds, in order to determine interactions and the best time to take it.